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Somatopause Reversal Strategies

Meaning

Somatopause Reversal Strategies are clinical interventions aimed at counteracting the somatopause, which is the age-related decline in the pulsatile secretion of Growth Hormone (GH) and the resulting decrease in its downstream mediator, Insulin-like Growth Factor 1 (IGF-1). This decline contributes to adverse body composition changes, reduced bone density, and diminished vitality. Reversal strategies seek to restore the somatotropic axis function to a more youthful state, thereby promoting anabolism, metabolic health, and tissue repair. The goal is to mitigate the catabolic state associated with GH deficiency in aging.