Somatopause Reversal refers to therapeutic interventions specifically designed to counteract the age-related decline in anabolic hormone status, most notably Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) signaling. This process aims to restore youthful physiological capacity by optimizing the endocrine milieu that supports tissue repair and body composition. We focus on mitigating the catabolic dominance often associated with advancing age. Reversal implies restoring function, not merely supplementing hormones.
Origin
The term is constructed from “somato” (body) and “pause” (cessation), describing the physiological slowing of growth-related endocrine functions typical in later life stages. It is a concept central to the anti-aging and regenerative medicine domains.
Mechanism
Reversal strategies often concentrate on maximizing endogenous GH secretion by optimizing sleep architecture, as the largest pulses occur during deep slow-wave sleep stages. Nutritional timing and specific amino acid administration can also enhance pituitary responsiveness to GHRH. Successful mechanism relies on improving the liver’s sensitivity to GH to boost IGF-1 production, thereby enhancing systemic anabolic signaling for tissue maintenance.
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