What is the Origin of Somatopause Protocols?

The term somatopause was coined by endocrinologists to describe the specific neuroendocrine aging process characterized by the gradual reduction in the GH-IGF-1 axis activity, distinct from other 'pauses' like andropause or menopause. The protocols evolved from pediatric endocrinology's understanding of GH deficiency, adapted for the subtle, age-related decline in adults. The focus is on reversing the associated symptoms of increased visceral fat and reduced lean mass.

What is the Mechanism of Somatopause Protocols?

The primary mechanism of these protocols is the indirect stimulation of the pituitary gland to secrete GH, thereby increasing the hepatic production of IGF-1, which mediates most of GH's anabolic effects. This stimulation works to restore the body's protein synthesis, lipolysis, and bone

Somatopause Protocols ∞ Area

Somatopause Protocols

Meaning

Somatopause Protocols are comprehensive clinical treatment plans designed to mitigate the physiological consequences of somatopause, the age-related decline in the production and secretion of Growth Hormone (GH) and its mediator, Insulin-like Growth Factor 1 (IGF-1). These protocols aim to restore the somatotropic axis function to a more youthful state to improve body composition, bone density, and overall metabolic health. Treatment typically involves the use of Growth Hormone-Releasing Hormones (GHRHs) or Growth Hormone-Releasing Peptides (GHRPs) rather than direct GH administration, prioritizing a physiological, pulsatile release. Continuous monitoring of IGF-1 is a key component for safety and efficacy.