What is the Origin of Somatopause Protocol?

The term combines "Somatopause" (the decline of the somatotropic axis with age) with "Protocol" (a detailed clinical plan). It emerged from anti-aging medicine and endocrinology as a therapeutic strategy to address the symptoms of adult growth hormone deficiency.

What is the Mechanism of Somatopause Protocol?

A typical Somatopause protocol involves the administration of Growth Hormone Secretagogues (GHSs), such as Sermorelin or Ipamorelin, or in some cases, exogenous GH itself, to stimulate the pituitary gland. The goal is to safely increase the pulsatile release of GH, which in turn elevates systemic IGF-1 levels, thereby promoting anabolic effects on muscle, bone, and metabolism.

Somatopause Protocol

Meaning

A clinical management plan specifically designed to counteract the physiological decline of the Somatotropic Axis—the age-related reduction in Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) secretion, known as Somatopause. The protocol aims to restore youthful levels and function to mitigate associated symptoms.