What is the Origin of Somatopause Progression?

The term is derived from "somato-" referring to the body and growth, and "-pause" denoting cessation or decline, specifically applied to the GH/IGF-1 axis. The concept was developed in endocrinology to distinguish the age-related decline in GH from other hormonal deficiencies, such as andropause or menopause. Understanding this progression is essential for evaluating potential anabolic deficiencies in older adults.

What is the Mechanism of Somatopause Progression?

The progression is primarily driven by changes in the hypothalamus, including a reduction in the release of Growth Hormone-Releasing Hormone (GHRH) and an increase in somatostatin, a potent GH-inhibitory peptide. This altered hypothalamic signaling dampens the pituitary's GH pulse amplitude and frequency, leading to lower circulating GH and subsequent lower hepatic IGF-1 production. The net result is a systemic shift toward a catabolic state with impaired cellular repair.

Somatopause Progression ∞ Area

Somatopause Progression

Meaning

Somatopause Progression describes the predictable, age-related decline in the function of the somatotropic axis, characterized by a progressive reduction in the pulsatile secretion of Growth Hormone (GH) and the resulting decrease in Insulin-like Growth Factor-1 (IGF-1) levels. This progression is a universal feature of human aging, leading to detrimental changes in body composition, including reduced lean mass and increased visceral fat accumulation. It is a primary hormonal contributor to sarcopenia and frailty.