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Somatopause Mitigation Strategies

Meaning

Somatopause Mitigation Strategies are clinical and lifestyle interventions specifically designed to counteract the somatopause, which is the inevitable age-related decline in the pulsatile secretion of growth hormone (GH) and subsequent reduction in insulin-like growth factor 1 (IGF-1). These strategies aim to restore a more youthful somatotropic axis function to preserve lean body mass, bone density, and basal metabolic rate. Mitigation is essential for preventing the associated sarcopenia, visceral adiposity, and general frailty of aging.