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Somatopause Endocrine Shift

Meaning

The Somatopause Endocrine Shift is the clinical term describing the progressive, age-related decline in the secretion of Growth Hormone (GH) and its primary mediator, Insulin-like Growth Factor 1 (IGF-1), which begins typically in early to mid-adulthood. This shift is a physiological hallmark of aging and contributes to a range of senescent changes, including decreased lean body mass, increased central adiposity, reduced bone mineral density, and compromised skin elasticity. Understanding this shift is critical for implementing targeted hormonal and metabolic interventions aimed at supporting healthy aging and functional longevity.