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Somatic Tissue Response

Meaning

Somatic tissue response refers to the measurable, physiological change exhibited by non-reproductive body tissues, such as muscle, bone, skin, and brain cells, following a specific hormonal or metabolic stimulus. This is the clinical endpoint that reflects the efficacy of a therapeutic intervention, moving beyond mere blood level measurements to assess actual cellular engagement and functional outcome. An optimal somatic tissue response signifies effective receptor signaling and downstream biological action.