The biological process involving the repair, renewal, or replacement of damaged or aged cells and tissues within the non-reproductive body structures, heavily reliant on appropriate endocrine signaling and metabolic support. This process is fundamental to maintaining structural integrity and functional capacity throughout the lifespan. It is cellular restoration at the organ level.
Origin
This concept originates in histology and regenerative medicine, emphasizing tissue repair, which is deeply modulated by systemic factors. In the context of hormonal health, it highlights the role of anabolic signals in rebuilding structure.
Mechanism
Regeneration is driven by the controlled proliferation and differentiation of stem or progenitor cells, processes heavily influenced by growth hormone, IGF-1, and sex steroids. These hormones regulate the expression of matrix metalloproteinases and growth factors that govern the breakdown of old matrix and the synthesis of new cellular components.
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