Skip to main content

Somatic Signaling

Meaning

Somatic Signaling refers to the intricate, complex, and bidirectional communication network that exists between the body’s peripheral tissues (the soma), such as skeletal muscle, adipose tissue, and bone, and the central regulatory centers, particularly the brain and major endocrine glands. This signaling involves the regulated release of specific molecules, known collectively as myokines, adipokines, and osteokines, which convey precise information about the metabolic and physical state of the originating tissue. Clinically, a thorough understanding of this systemic communication is essential for accurately interpreting systemic health, metabolic resilience, and disease states. It is the molecular, ongoing conversation of the body’s structural components.