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Somatic Drift Resistance

Meaning

Somatic drift resistance refers to the biological capacity of an organism’s cells to maintain genetic and epigenetic integrity over time, actively resisting the accumulation of detrimental somatic mutations and epigenetic alterations that drive cellular senescence and aging. This intrinsic resilience is a critical determinant of healthspan and longevity, directly linked to the efficiency of DNA repair mechanisms and the fidelity of cellular replication. Hormonal factors, particularly those related to growth and metabolism, play a modulatory role in maintaining this resistance.