The measurable velocity at which non-germline cells replace damaged components, repair DNA lesions, or undergo controlled turnover to maintain tissue functional capacity throughout the body. These rates are fundamentally influenced by the systemic anabolic environment maintained by endocrine signaling. Declining rates are a hallmark of physiological aging.
Origin
This term stems from cellular gerontology and tissue biology, focusing on the kinetics of cellular maintenance outside of specialized immune or reproductive systems. Its integration with endocrinology recognizes hormones as primary regulators of cellular turnover and protein accretion. It quantifies the efficiency of biological renewal.
Mechanism
Repair rates are governed by the availability of necessary building blocks and the activity of DNA repair enzymes, both heavily influenced by anabolic hormones like testosterone and IGF-1. Adequate circulation ensures the timely delivery of these substrates and signaling factors to the tissue level. Conversely, chronic stress elevates catabolic hormones that suppress these essential repair processes.
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