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Solid-Phase Peptide Synthesis (SPPS)

Meaning

Solid-Phase Peptide Synthesis (SPPS) is a chemical methodology for the laboratory production of peptides, which involves sequentially adding protected amino acid residues to a growing peptide chain that is covalently anchored to an insoluble resin bead. This technique fundamentally revolutionized peptide chemistry by allowing for rapid, automated, and high-yield synthesis of complex peptide sequences, including many therapeutic peptide hormones and modulators. The final peptide is cleaved from the resin and meticulously purified after the desired sequence is fully assembled.