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Sleep-Related Metabolic Dysfunction

Meaning

Sleep-related metabolic dysfunction is a clinical condition where chronic disturbances in the duration, quality, or circadian timing of sleep lead to a measurable impairment in the body’s metabolic and endocrine regulatory processes. This dysfunction is strongly associated with adverse health outcomes, including the development of insulin resistance, glucose intolerance, and an increased risk of Type 2 diabetes and obesity. Conditions like obstructive sleep apnea, or OSA, and chronic sleep deprivation are recognized as independent risk factors that disrupt the delicate hormonal balance governing energy homeostasis.