The array of endocrine signaling molecules, including melatonin, cortisol, growth hormone, and thyroid hormones, that are intricately involved in regulating the circadian rhythm, sleep architecture, and the restorative processes that occur during sleep. The nocturnal secretion patterns of these hormones are critical for metabolic regulation, immune function, and neurocognitive repair. Clinical assessment often focuses on restoring the appropriate temporal release of these key endocrine agents to optimize health.
Origin
This term emerges from the convergence of chronobiology, sleep medicine, and endocrinology, recognizing that sleep is a period of intense hormonal activity, not just rest. The discovery of melatonin’s role in the sleep-wake cycle solidified the hormonal link to sleep quality. This understanding is fundamental to treating sleep disorders and promoting longevity.
Mechanism
Melatonin, secreted by the pineal gland, signals darkness and initiates the cascade of events leading to sleep onset and maintenance of the circadian rhythm. Cortisol levels typically decrease before sleep and rise toward morning, a pattern that is often disrupted by chronic stress. Concurrently, growth hormone is released primarily during deep non-REM sleep, facilitating tissue repair and metabolic homeostasis, underscoring the vital role of these hormones in restorative physiology.
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