What is the Origin of Sleep Onset GH Surge?

A descriptive endocrinological term combining 'Sleep Onset' (the beginning of sleep), the abbreviation 'GH' (Growth Hormone), and 'Surge' (a sudden, powerful increase). It is a hallmark of nocturnal endocrine function.

What is the Mechanism of Sleep Onset GH Surge?

The surge is driven by the nocturnal increase in Growth Hormone-Releasing Hormone (GHRH) and the concurrent decrease in somatostatin release from the hypothalamus, synchronized with the onset of slow-wave brain activity. This massive pulse of GH initiates a cascade of downstream anabolic effects, including hepatic IGF-1 production, which is essential for overnight tissue repair and metabolic regulation.

Sleep Onset GH Surge ∞ Area

Sleep Onset GH Surge

Meaning

The distinct, high-amplitude pulsatile release of Growth Hormone (GH) from the anterior pituitary gland that reliably occurs shortly after the initiation of deep, slow-wave sleep (NREM Stage 3/4). This surge is the largest GH secretory event of the 24-hour cycle.

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