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Sleep-Induced Hypogonadism

Meaning

Sleep-Induced Hypogonadism describes a state of functional hormonal dysregulation where chronic, insufficient, or poor-quality sleep leads to a measurable suppression of the Hypothalamic-Pituitary-Gonadal (HPG) axis, resulting in pathologically low levels of circulating sex hormones, primarily testosterone. This condition is not due to primary gonadal failure but rather to a central, sleep-mediated disruption of the neuroendocrine signals that regulate hormone production. It is a key example of how lifestyle factors directly influence endocrine health and is reversible with sleep optimization.