What is the Origin of Sleep for Longevity?

This perspective integrates modern research from gerontology, endocrinology, and chronobiology, which collectively demonstrate the profound impact of chronic sleep debt on biological aging markers. The term elevates sleep from a mere rest state to an active, life-extending biological process.

What is the Mechanism of Sleep for Longevity?

Restorative sleep supports longevity by optimizing the nocturnal release of growth hormone and melatonin, both potent anti-aging and antioxidant agents. Furthermore, sleep facilitates the Nightly Glymphatic Clearance, which prevents the accumulation of neurotoxic proteins linked to age-related cognitive decline. Chronic sleep restriction, conversely, elevates cortisol and pro-inflammatory cytokines, accelerating cellular senescence and increasing the risk of metabolic and cardiovascular diseases, thereby shortening healthspan.

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Sleep for Longevity

Meaning

Sleep for Longevity is a clinical paradigm that posits high-quality, sufficient sleep as a fundamental, non-negotiable pillar of a long and healthy lifespan, directly influencing cellular aging and disease risk. This concept recognizes sleep’s essential role in modulating systemic inflammation, maintaining DNA integrity, and regulating the hormonal balance associated with healthy aging. Prioritizing sleep is a direct investment in extending healthspan.