Sleep Debt Hormonal Accounting is the physiological and clinical concept that insufficient sleep, or sleep debt, results in measurable and detrimental shifts in the balance and timing of key regulatory hormones. This metabolic and endocrine disruption includes changes in cortisol, insulin, ghrelin, and leptin levels, directly impacting stress resilience, glucose metabolism, and appetite regulation. The term emphasizes the tangible biological cost of chronic sleep deprivation.
Origin
The concept emerged from sleep and endocrinology research demonstrating that sleep restriction has immediate and dose-dependent effects on endocrine function, similar to a metabolic stressor. Accounting is a metaphor highlighting the body’s meticulous tracking of this deficit and the subsequent compensatory hormonal adjustments. It connects a behavioral deficit directly to quantifiable hormonal endpoints, underscoring the body’s need for recovery.
Mechanism
Acute sleep debt leads to increased evening cortisol levels, impairing glucose tolerance and promoting insulin resistance, essentially mimicking a state of chronic stress. Concurrently, there is a profound shift in appetite-regulating hormones: ghrelin, the hunger hormone, increases, while leptin, the satiety hormone, decreases. This hormonal imbalance drives increased caloric intake and favors fat storage, demonstrating the systemic impact of insufficient nightly recovery.
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