What is the Origin of SLCO1B1 Gene?

SLCO1B1 is an abbreviation for Solute Carrier Organic Anion Transporter Family Member 1B1, placing it within a larger family of transporter proteins. Its discovery and functional characterization are part of the broader efforts in pharmacogenomics to map genes that govern drug disposition. The gene's clinical relevance was dramatically highlighted by its association with statin-induced myopathy.

What is the Mechanism of SLCO1B1 Gene?

The OATP1B1 protein acts as an influx transporter, actively moving its substrate molecules from the bloodstream into the hepatocyte cytoplasm. Genetic variants in SLCO1B1 can impair the transporter's function, leading to reduced drug uptake by the liver. Consequently, the drug remains at higher concentrations in the systemic circulation, increasing the risk of dose-dependent toxicity in non-hepatic tissues like muscle.

SLCO1B1 Gene ∞ Area

SLCO1B1 Gene

Meaning

The SLCO1B1 gene provides the genetic blueprint for synthesizing the organic anion transporting polypeptide 1B1 (OATP1B1), a crucial transporter protein primarily expressed on the membrane of liver cells. This protein is fundamentally responsible for the hepatic uptake of numerous endogenous compounds, including bilirubin, and various therapeutic agents, such as statins. Genetic variations, or polymorphisms, within this gene significantly influence drug pharmacokinetics and the risk of adverse drug reactions. Understanding a patient’s genotype is key to personalized dosing.