Question 1

What is the Meaning of SLCO1B1?

Accepted Answer

SLCO1B1 encodes the Solute Carrier Organic Anion Transporter Family Member 1B1 protein, a crucial transporter for moving specific compounds from the blood into liver cells. This protein is essential for the hepatic uptake of numerous endogenous substances, including bilirubin and bile acids, as well as various medications like statins and certain antibiotics. Genetic variations within this gene can significantly impact an individual's capacity to process and eliminate these substances.

Question 2

What is the Context of SLCO1B1?

Accepted Answer

The SLCO1B1 transporter is predominantly situated on the sinusoidal membrane of hepatocytes, the primary functional cells of the liver. Within this anatomical context, it acts as a selective gateway, facilitating the efficient transfer of its substrates from systemic circulation into the liver parenchyma. This strategic localization ensures that the liver can effectively clear compounds from the bloodstream, initiating their metabolism or excretion from the body.

Question 3

What is the Significance of SLCO1B1?

Accepted Answer

The clinical importance of SLCO1B1 lies in its profound influence on drug disposition and the potential for adverse drug reactions. Polymorphisms in this gene are well-established determinants of inter-individual variability in drug response, particularly for statins, a class of cholesterol-lowering medications. Understanding a patient's SLCO1B1 genotype can inform personalized prescribing decisions, aiming to enhance therapeutic efficacy and minimize the risk of unwanted side effects.

Question 4

What is the Mechanism of SLCO1B1?

Accepted Answer

SLCO1B1 mediates the active, sodium-independent transport of its substrates across the hepatocyte membrane. This process involves specific binding of organic anions to the transporter protein, followed by a conformational change that moves the compound into the cell. The transporter's function contributes directly to the first pass effect for orally administered drugs and the overall systemic clearance of various xenobiotics and endogenous metabolites.

Question 5

What is the Application of SLCO1B1?

Accepted Answer

In contemporary clinical practice, pharmacogenomic testing for SLCO1B1 variants, particularly the c.521T>C (rs4149056) polymorphism, is increasingly utilized. This testing helps predict a patient's risk of statin-induced myopathy, a common and potentially severe adverse effect. Healthcare providers can use this genetic information to adjust statin dosages or select alternative lipid-lowering therapies, thereby tailoring treatment plans to individual genetic profiles.

Question 6

What is the Metric of SLCO1B1?

Accepted Answer

The functional status of SLCO1B1 is typically assessed through genetic analysis, identifying specific single nucleotide polymorphisms known to alter transporter activity. While direct measurement of SLCO1B1 protein levels or activity in vivo is not routine, the clinical consequences of its variations are observed as altered plasma concentrations of its substrate drugs or the manifestation of drug-related toxicities. Monitoring these clinical parameters provides indirect insight into its function.

Question 7

What is the Risk of SLCO1B1?

Accepted Answer

Impaired SLCO1B1 function, often due to genetic polymorphisms, significantly elevates the risk of systemic drug accumulation and subsequent toxicity. For example, individuals with reduced-function SLCO1B1 variants who take certain statins may experience higher plasma drug levels, leading to an increased susceptibility to myopathy, characterized by muscle pain and weakness. Prudent clinical management requires careful consideration of these genetic risks to prevent adverse outcomes.

SLCO1B1

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

How Do Genetic Variations Affect Peptide Absorption and Distribution?

How Does Genetic Testing Improve Hormone Therapy Safety?