Skip to main content

SLC6A4

Meaning

SLC6A4 is the scientific designation for the Solute Carrier Family 6 Member 4 gene, which provides the genetic blueprint for the Serotonin Transporter (SERT), also known as 5-HTT. This critical membrane protein is responsible for the reuptake of the neurotransmitter serotonin from the synaptic cleft back into the presynaptic neuron, thereby regulating the intensity and duration of serotonergic signaling. Genetic variations, particularly a common polymorphism in the promoter region, are studied in relation to individual differences in mood regulation, stress response, and the efficacy of certain psychotropic medications.