What is the Origin of SLC15A1?

The nomenclature is based on the standardized genetic classification of membrane transport proteins, placing it within the Solute Carrier (SLC) superfamily. Its function was elucidated through molecular biology and physiological studies that sought to understand the final stage of protein assimilation. This transporter is a key focus in nutritional science and peptide pharmacology.

What is the Mechanism of SLC15A1?

PEPT1 operates as a proton-coupled symporter, utilizing the inward electrochemical proton gradient across the intestinal cell membrane to drive the active uptake of di- and tripeptides against their concentration gradient. This mechanism allows for the rapid and efficient absorption of the vast majority of dietary protein, as peptides are preferentially absorbed over free amino acids. Furthermore, PEPT1 can also transport certain peptide-mimetic drugs, making it a crucial determinant of the oral bioavailability of many therapeutic agents.

SLC15A1 ∞ Area

SLC15A1

Meaning

SLC15A1 stands for Solute Carrier Family 15 Member 1, a gene that encodes the Peptide Transporter 1 (PEPT1), which is a critical membrane protein primarily expressed on the apical surface of enterocytes in the small intestine. This transporter is fundamentally responsible for the absorption of dipeptides and tripeptides, the final products of protein digestion, from the intestinal lumen into the cell. Optimal function of SLC15A1 is essential for efficient protein utilization and the overall anabolic state of the body.