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Skin Permeability

Meaning

Skin permeability is a critical biophysical property that quantitatively measures the ease with which external substances can successfully pass through the stratum corneum and subsequently penetrate into the deeper layers of the epidermis and dermis. This essential barrier function is non-negotiable for preventing the ingress of pathogens and environmental toxins while simultaneously minimizing transepidermal water loss, thereby maintaining optimal skin hydration. Skin permeability is a paramount consideration in the development of transdermal drug delivery systems, as it directly dictates the systemic bioavailability of topically applied hormonal agents.