What is the Origin of Skin Lipid Profile?

The term combines "skin" and "lipid profile," referring to the chemical composition of the fat molecules. Its origin lies in biochemistry and dermatological barrier function research, specifically focusing on the critical role of the epidermal lipids in preventing dehydration and protecting against environmental pathogens. The analysis of this profile is a key metric in cosmetic science and clinical dermatology.

What is the Mechanism of Skin Lipid Profile?

The synthesis and secretion of specific ratios of ceramides, cholesterol, and free fatty acids by differentiating keratinocytes are crucial for the formation of the ordered, water-impermeable lipid matrix in the stratum corneum intercellular space. A deficiency or imbalance in this profile, often seen in conditions like atopic dermatitis or advanced aging, compromises the barrier integrity, leading to increased susceptibility to irritants and heightened transepidermal water loss. Hormones like glucocorticoids can directly influence the synthesis of these barrier lipids.

Skin Lipid Profile ∞ Area

Skin Lipid Profile

Meaning

The specific qualitative and quantitative composition of the various lipid classes, including ceramides, cholesterol, free fatty acids, and triglycerides, that are present within the epidermis and on the skin surface. This profile is essential for forming the highly structured lamellar bilayers of the stratum corneum, which constitute the primary permeability barrier of the skin. An optimal skin lipid profile is a clinical indicator of robust barrier function and minimized transepidermal water loss.