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Skin Lipid Barrier Function

Meaning

Skin Lipid Barrier Function describes the essential protective role of the lipid matrix within the stratum corneum, the outermost layer of the epidermis, in regulating transepidermal water loss (TEWL) and preventing the entry of irritants and pathogens. This barrier is a precisely organized structure composed primarily of ceramides, cholesterol, and fatty acids, which form a crucial seal. Optimal function is critical for maintaining skin hydration, integrity, and immune defense. Compromise of this function leads to chronic dryness, sensitivity, and increased risk of inflammation and infection.