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Skeletal Remodeling

Meaning

Skeletal Remodeling is the continuous, highly organized, and lifelong physiological process that involves the perfectly coupled actions of bone resorption, carried out by specialized osteoclast cells, and subsequent new bone formation, performed by osteoblast cells, all occurring within the existing bone matrix. This dynamic process serves the critical functions of repairing accumulated micro-damage, maintaining systemic mineral homeostasis, and adapting the skeleton’s structure to changing mechanical load demands. A precise and sustained balance between the rates of resorption and formation is absolutely crucial for maintaining optimal bone strength and preventing debilitating conditions like osteoporosis.