What is the Origin of Skeletal Muscle Endocrinology?

The recognition of skeletal muscle as an active endocrine organ is a relatively recent paradigm shift in physiology, moving beyond its traditional role as a simple effector of movement. This realization stemmed from the discovery and characterization of myokines, which established muscle as an active participant in metabolic and immune regulation. This area of study is now central to understanding sarcopenia, metabolic syndrome, and the benefits of physical activity.

What is the Mechanism of Skeletal Muscle Endocrinology?

Muscle contraction and metabolic state stimulate the release of myokines, such as Interleukin-6 (IL-6) and Irisin, which travel through the circulation to influence the function of adipose tissue, liver, and brain. For example, Irisin is linked to the browning of white fat, enhancing thermogenesis. Furthermore, classic hormones like insulin, testosterone, and IGF-1 directly regulate muscle protein synthesis and glucose uptake, demonstrating a reciprocal regulatory loop between the endocrine system and muscle tissue.

Skeletal Muscle Endocrinology ∞ Area

Skeletal Muscle Endocrinology

Meaning

The specialized field of endocrinology that investigates the role of skeletal muscle as a major endocrine organ capable of synthesizing and secreting signaling molecules called myokines, which exert autocrine, paracrine, and endocrine effects throughout the body. This discipline studies the complex hormonal regulation of muscle mass and function, and its profound influence on systemic metabolism, bone health, and immune function. It highlights the dynamic communication between muscle and other vital organs.