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Skeletal Muscle Endocrine Function

Meaning

Skeletal muscle endocrine function describes the capacity of muscle tissue to act as an endocrine organ, synthesizing and releasing various signaling molecules, collectively termed myokines, into the circulation to influence distant organs. This function is a critical component of metabolic health, extending the role of muscle far beyond locomotion and strength. The myokines released exert pleiotropic effects on fat metabolism, immune function, bone density, and even brain health. Recognizing and supporting this endocrine role is central to modern longevity and wellness protocols.