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Skeletal Muscle Crosstalk

Meaning

Skeletal muscle crosstalk describes the intricate bidirectional communication network between skeletal muscle tissue and other distant organs, including adipose tissue, liver, bone, and the brain, mediated by the secretion of signaling molecules called myokines. This dynamic endocrine function of muscle is crucial for regulating systemic metabolism, insulin sensitivity, and chronic inflammation. Viewing muscle as an endocrine organ is a paradigm shift in metabolic and hormonal health.