What is the Origin of Skeletal Health?

The clinical focus on skeletal health intensified with the recognition of osteoporosis as a major public health concern, particularly in postmenopausal women, highlighting the critical role of bone density in preventing fragility fractures. This led to the development of specialized diagnostic tools like Dual-energy X-ray Absorptiometry (DXA).

What is the Mechanism of Skeletal Health?

The mechanism of maintaining skeletal integrity is a continuous process of bone remodeling, involving the balanced activity of osteoclasts, which resorb old bone, and osteoblasts, which form new bone matrix. Sex steroids, particularly estrogen, play a crucial role by inhibiting osteoclast activity and promoting osteoblast function. Hormonal decline, such as that seen in menopause or andropause, disrupts this balance, leading to accelerated bone resorption and a net loss of bone mass, thereby compromising structural strength.

Skeletal Health

Meaning

Skeletal health refers to the physiological state of the bone tissue, characterized by optimal bone mineral density, robust microarchitecture, and a balanced rate of bone turnover, which collectively ensure the structural integrity and resistance to fracture. Bone is a dynamic endocrine tissue, and its health is inextricably linked to the balance of various hormones, including parathyroid hormone, calcitonin, vitamin D, and the sex steroids. Maintaining skeletal health is a critical component of healthy aging and physical independence.

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