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Sirtuins

Meaning

A family of NAD+-dependent deacetylase enzymes (SIRT1-SIRT7) that function as critical cellular sensors of metabolic stress and energy status, playing a central role in regulating longevity, DNA repair, and gene silencing. These enzymes link the cell’s energy currency (NAD+) directly to its transcriptional response, thereby modulating metabolic pathways, inflammation, and mitochondrial function. They are key targets in the clinical pursuit of healthspan extension.