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Sirtuin Pathway Upregulation

Meaning

Sirtuin Pathway Upregulation describes the targeted increase in the activity of the sirtuin family of proteins, specifically the NAD+-dependent deacetylases, which function as critical metabolic sensors and regulators of cellular stress response, DNA repair, and epigenetic silencing. In the context of hormonal health and longevity, upregulating these pathways is a key strategy to enhance cellular resilience, improve mitochondrial function, and indirectly modulate endocrine signaling by optimizing the cellular environment. This action slows the physiological processes associated with hormonal aging and metabolic decline.