What is the Origin of Sirtuin Pathway Support?

This term arises from the cutting-edge field of longevity research, specifically the study of sirtuins (SIRT1-SIRT7), which are evolutionarily conserved enzymes linking nutrient availability to cellular defense. The concept of "support" translates this molecular discovery into a practical clinical intervention, focusing on the upstream activators and necessary substrates required for optimal enzymatic function.

What is the Mechanism of Sirtuin Pathway Support?

Sirtuin enzymes require Nicotinamide Adenine Dinucleotide (NAD+) as an essential cofactor to perform their deacetylase function, which removes acetyl groups from target proteins to regulate gene expression and metabolic pathways. Support mechanisms, therefore, focus on boosting intracellular NAD+ levels, often through precursors like Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN), and using phytochemical activators (e.g., resveratrol) to enhance the catalytic rate of the sirtuin enzymes themselves.

Sirtuin Pathway Support ∞ Area

Sirtuin Pathway Support

Meaning

The clinical strategy of enhancing the activity of the sirtuin family of NAD+-dependent deacetylase enzymes, which function as master regulators of cellular health, DNA repair, and longevity. This support aims to optimize the cellular environment and provide necessary cofactors to maximize sirtuin-mediated signaling. Activated sirtuins promote genomic stability, suppress inflammation, and increase mitochondrial efficiency, which are key aspects of anti-aging and metabolic health.