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Sirtuin Pathway Modulation

Meaning

Sirtuin pathway modulation is the therapeutic or lifestyle-based strategy of purposefully regulating the activity of sirtuins, a family of NAD+-dependent protein deacetylases and ADP-ribosyltransferases that govern critical cellular homeostatic processes. These enzymes are recognized as key regulators of metabolic function, cellular stress resistance, and DNA repair, making their precise modulation a central focus in longevity and metabolic health research. Activating these pathways is a strategy pursued to enhance cellular resilience against the accumulated damage associated with biological aging.