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Sirtuin Activity

Meaning

Sirtuin activity refers to the enzymatic function of the sirtuin family of proteins, a class of NAD+-dependent deacetylases and ADP-ribosyltransferases found in various cellular compartments. These enzymes are critical regulators of cellular metabolism, DNA repair, gene silencing, and stress resistance, playing a pivotal role in cellular longevity and survival. The level of sirtuin activity is intrinsically linked to the cell’s energy status, acting as a metabolic sensor that couples nutrient availability with gene expression.