What is the Origin of Sirtuin Activation Compounds?

The term is rooted in molecular biology and aging research, following the discovery of sirtuins (SIRT1-7) and their role as key regulators of cellular health. The most well-known activator, resveratrol, popularized the concept of "activation compounds." This field is a modern extension of nutritional biochemistry and targeted pharmacology.

What is the Mechanism of Sirtuin Activation Compounds?

Sirtuins function as metabolic sensors, requiring the coenzyme NAD+ to perform their deacetylase activity, which removes acetyl groups from target proteins like histones and transcription factors. Sirtuin Activation Compounds work by stabilizing the sirtuin-substrate complex, effectively lowering the required concentration of NAD+ for activity. This increased activity enhances DNA repair, improves mitochondrial function, and modulates inflammatory signaling, thereby promoting cellular survival and longevity pathways.

Sirtuin Activation Compounds ∞ Area

Sirtuin Activation Compounds

Meaning

Sirtuin Activation Compounds are a class of molecules, often naturally derived or synthetic, that are capable of enhancing the enzymatic activity of sirtuins, a family of NAD+-dependent protein deacetylases central to cellular stress response, DNA repair, and metabolic regulation. These compounds are of significant clinical interest in longevity science because their activation mimics the beneficial effects of caloric restriction, promoting cellular resilience and extending healthspan. The strategic use of these compounds is a promising avenue for modulating the aging process.