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Sirtuin Activation

Meaning

Sirtuin Activation is the process of increasing the functional activity of sirtuins, a family of NAD+-dependent deacetylase enzymes (SIRT1-SIRT7) that play a crucial, conserved role in regulating cellular metabolism, DNA repair, and stress resistance. Clinically, the activation of these enzymes, particularly SIRT1, is a primary strategy in longevity and metabolic health protocols, as their enhanced function is associated with improved insulin sensitivity, reduced systemic inflammation, and the stabilization of genomic integrity. This process is often targeted through specific nutritional compounds and lifestyle interventions.