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SIRT3-NLRP3 Axis

Meaning

The SIRT3-NLRP3 Axis is a critical intracellular signaling pathway that links mitochondrial health and metabolic regulation to the innate immune system’s inflammatory response. Sirtuin 3 (SIRT3) is a major mitochondrial deacetylase enzyme that acts as a key regulator of cellular energy and antioxidant defense, while the NLRP3 inflammasome is a multi-protein complex that triggers the release of potent pro-inflammatory cytokines. This axis is central to understanding the cellular mechanisms of aging, longevity, and chronic inflammation, which profoundly impact hormonal balance and metabolic wellness. It represents a fundamental point of cellular control.