What is the Origin of Sirt-1 Activation?

The term is rooted in longevity research and cellular metabolism, stemming from the discovery of the Sirtuin family of proteins, which are highly conserved across species and directly linked to the benefits of caloric restriction. The name is an abbreviation for Silent Information Regulator 2 homolog 1.

What is the Mechanism of Sirt-1 Activation?

Activation is achieved by compounds or lifestyle factors that increase the availability of the co-factor NAD+ or directly enhance the enzyme's binding affinity. Once activated, SIRT1 removes acetyl groups from various target proteins, including transcription factors like NF-κB and PGC-1alpha, thereby coordinating a protective cellular response that shifts metabolism toward energy efficiency and cellular maintenance.

Sirt-1 Activation ∞ Area

Sirt-1 Activation

Meaning

Sirt-1 Activation refers to the pharmacological or physiological process of increasing the enzymatic activity of Sirtuin 1 (SIRT1), a key NAD+-dependent protein deacetylase enzyme often called a longevity protein. Enhanced SIRT1 activity is a crucial cellular event that promotes DNA repair, boosts mitochondrial function, suppresses inflammatory pathways, and significantly enhances cellular stress resistance, all of which contribute to a longer health span.