What is the Origin of Single Nucleotide Polymorphism Analysis?

The concept and analysis of SNPs emerged from the sequencing of the human genome, revealing that these common variations are the most frequent type of genetic difference among people. This discovery enabled the field of pharmacogenomics and personalized risk assessment.

What is the Mechanism of Single Nucleotide Polymorphism Analysis?

The analysis involves sequencing specific regions of the genome to compare an individual's base pair at a known polymorphic site against the common reference allele. The identified variation can alter the resulting protein's structure or expression, thereby changing the efficiency of a biological pathway. This genetic insight allows clinicians to tailor nutritional, supplemental, and hormonal therapies to circumvent or support an individual's unique biochemical predisposition.

Single Nucleotide Polymorphism Analysis ∞ Area

Single Nucleotide Polymorphism Analysis

Meaning

Single Nucleotide Polymorphism Analysis (SNP Analysis) is a molecular diagnostic technique used to identify variations in a single base pair of DNA that occur across a population, serving as critical genetic markers that influence individual biological responses and disease susceptibility. Clinically, this analysis is vital for understanding personalized medicine, as SNPs can affect the function of enzymes involved in drug metabolism, hormone synthesis, detoxification, and nutrient utilization, such as the MTHFR or COMT genes.