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Signaling Pathway Cross-Talk

Meaning

The intricate process by which different cellular communication routes, or signaling pathways, interact with and influence one another within a cell or across different cell types. This cross-talk allows the cell to integrate multiple external and internal signals—such as those from insulin, growth factors, and stress hormones—to generate a nuanced, context-dependent biological response. Dysregulation of this integration is a hallmark of metabolic and endocrine disease.