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Signal Matching

Meaning

Signal Matching is a principle in precision endocrinology and cellular communication that aims to synchronize the delivery and profile of an exogenous hormone or therapeutic agent with the body’s natural, or endogenous, rhythmic signaling pattern. This goes beyond simple dose replacement by considering the pulsatility, diurnal variation, and receptor sensitivity inherent to the body’s native hormonal kinetics. Clinically, Signal Matching is used to optimize outcomes and minimize side effects, for instance, by timing testosterone or growth hormone secretagogue administration to mimic the body’s natural peak secretion times. Achieving this synchronization is key to restoring youthful hormonal function.