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Signal Integrity Failure

Meaning

Signal Integrity Failure describes a state of pathological dysfunction within the neuroendocrine system where the communication between signaling molecules and their target receptors is compromised or inefficient. This failure can manifest as reduced receptor sensitivity, impaired signal transduction cascades, or increased hormone clearance rates, leading to a blunted or inappropriate physiological response despite adequate hormone levels. Clinically, this is a common root cause of functional hormonal deficiency, even when circulating hormone concentrations appear normal. This breakdown in communication undermines systemic health.