Signal Fidelity Biology is a comprehensive biological principle focused on the accuracy, clarity, and non-degradation of communication signals transmitted between cells, tissues, and organs, particularly within the neuroendocrine system. Maintaining high fidelity is paramount for healthy, coordinated function and systemic longevity. Errors in this communication can lead to metabolic and hormonal dysfunction.
Origin
This conceptual framework integrates principles from information theory and molecular biology, viewing biological signaling as a complex communication channel susceptible to noise and error from internal and external stressors. It is a guiding principle in advanced longevity research and precision medicine.
Mechanism
Fidelity relies on the precise release of signaling molecules, the correct three-dimensional structure of receptor proteins, and the efficient downstream transduction of the message within the target cell. Errors in this process, often caused by chronic inflammation, oxidative stress, or age-related protein damage, can lead to receptor insensitivity and functional decline.
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