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Short-Chain Fatty Acids Brain

Meaning

Short-Chain Fatty Acids (SCFAs) Brain refers to the direct and indirect influence of the microbial metabolites, primarily acetate, propionate, and butyrate, on the central nervous system’s function, structure, and neuroendocrine signaling. These fatty acids, produced by the fermentation of dietary fiber in the gut, act as crucial signaling molecules that can cross the blood-brain barrier or signal via the vagus nerve and systemic circulation. Their presence is essential for maintaining brain health, regulating mood, and modulating neuroinflammation.