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Shift Work Metabolism

Meaning

Shift work metabolism describes the physiological and endocrine disturbances that occur when an individual’s work schedule forces activity during the body’s natural nocturnal rest phase, leading to chronic misalignment of the central and peripheral circadian clocks. This metabolic disruption is characterized by impaired glucose tolerance, reduced insulin sensitivity, and dysregulation of appetite-controlling hormones like leptin and ghrelin. Clinically, shift work is a recognized risk factor for metabolic syndrome, cardiovascular disease, and increased systemic inflammation due to the chronic stress it imposes on the endocrine system. It represents a significant public health challenge requiring targeted metabolic support.