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SHBG Regulation Protocols

Meaning

SHBG Regulation Protocols are clinical and nutritional strategies specifically implemented to modulate the concentration of Sex Hormone-Binding Globulin (SHBG), a glycoprotein synthesized in the liver that binds to and inactivates sex steroids, primarily testosterone and estradiol. The primary clinical objective is to manage SHBG levels to optimize the bioavailability of free, biologically active hormones at the tissue level. These protocols are essential when total hormone levels are adequate but high SHBG is suppressing the free fraction, or when low SHBG leads to excessive free hormone exposure. Regulation is key to achieving true endocrine balance and mitigating side effects.