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SHBG Ratio Management

Meaning

SHBG Ratio Management is the clinical practice of monitoring and strategically modulating the concentration of Sex Hormone-Binding Globulin (SHBG) in the circulation to optimize the ratio of free, biologically active steroid hormones, particularly testosterone and estradiol. Since SHBG binds to these hormones and renders them inactive, managing its levels is crucial for ensuring adequate hormone availability at the tissue level, irrespective of total hormone concentration. Clinically, this management is essential for addressing symptoms of hormonal excess or deficiency that may not be apparent from total hormone measurements alone. The goal is to fine-tune the delivery system for sex hormones.