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SHBG Ratio Assessment

Meaning

SHBG Ratio Assessment is a clinical evaluation focused on calculating and interpreting the ratio between Sex Hormone Binding Globulin (SHBG) and one or more of its primary binding partners, typically testosterone or estradiol. This ratio serves as an inverse proxy for the availability of free, biologically active sex hormones, providing critical insight into metabolic and endocrine health. A high SHBG-to-Testosterone ratio, for example, suggests reduced free androgen activity, even if total testosterone is within the normal range. This assessment is vital for fine-tuning hormonal interventions and understanding underlying metabolic drivers.